|
KMID : 0381120230450111409
|
|
Genes and Genomics
2023 Volume.45 No. 11 p.1409 ~ p.1422
|
|
|
TAS2R38 bitter taste perception in the Ko?ka?? S?rasvata Brahmin population
|
|
Jaison Jeevan Sequeira
Sheikh Nizamuddin
George van Driem
Mohammed S. Mustak
|
|
|
Abstract
|
|
|
Background : The TAS2R38 gene carries markers for phenylthiocarbamide (PTC) sensitivity. Various studies have investigated the genotype?phenotype association pattern for bitter tasting ability and other factors in different populations. However, a paucity of such information for endogamous Indian populations is the reason behind this study.
Objective : To study the association of phenylthiocarbamide (PTC) sensitivity with TAS2R38 gene variations in Ko?ka?? S?rasvata Brahmin population.
Methods : We studied the association of the alleles rs714598, rs1726866, rs10246939 with PTC sensitivity and other factors in the Ko?ka?? S?rasvata Brahmin population. DNA was extracted from 114 individuals belonging to the Ko?ka?? S?rasvata Brahmin community. The TAS2R38 gene was sequenced to find the genotype distribution pattern. The association between genotype and phenotype was checked using the Chi-Square test and multifactorial logistical regression.
Results : We observed a 58.8% frequency of the AVI haplotype, which is the most prevalent in European populations. A higher number of non-taster haplotypes and diplotypes were observed in Ko?ka?? S?rasvata Brahmins, with the allele rs10246939 showing a significant association with PTC bitter taste sensitivity in both allelic (p?=?8.6?×?10?4; Allele-G, OR?=?3.57 [95% CI?=?1.66?7.69]) and genotype-based (p?=?6.9?×?10?4; genotype-AG, OR?=?3.11 [95% CI?=?0.73?13.20]; genotype-GG, OR?=?40 [95% CI?=?3.58?447.03]) tests.
Conclusion : Our results are in line with earlier studies, which report an association between PTC sensitivity and the TAS2R38 gene in different populations. In the global context, Ko?ka?? S?rasvata Brahmins, who are mostly distributed along the southwestern coast of India, show a PTC sensitivity pattern slightly similar to that of West Eurasian populations. Our findings suggest ancestry specific selection in TAS2R38 gene variations for taste sensitivity at global level.
|
|
|
KEYWORD
|
|
|
TAS2R38 gene, Bitter tasters, PTC, Genotype phenotype association, Konkani Sarasvata Brahmin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|